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strings concert HIV virus uses the protein Vif to reactivate multifaceted

One obstacles for AIDS treatment has been, for several years and recognized the virus's ability to remain in a dormant state. If patients stop taking their medications or are weakened by some other infection the virus appears to emerge, and sometimes in a more resistant to treatment. One strategy of viruses to monitor the success and level of infection is through the manipulation of some of the proteins involved in cell cycle of infected cells. Therefore, research focusing on understanding the molecular mechanisms involved in this process could, eventually, help to design more successful therapies aimed at eliminating HIV reservoirs and the reestablishment of the functions of the immune system of patients infected. have already identified several proteins that are used by HIV to amend cell cycle of infected cells. For example, the viral protein called Vif (viral infectivity factor ) is involved in the forced retention of cells in G2 phase cell cycle is a period of rapid cell growth and is exactly where the transcription of viral genome is optimal. Vif protein prevents the cells to grow at that stage. structural diagram of HIV. Image taken from Wikimedia Commons . In a recent study , led by Terry H. Finkel and Jiangfang Wang The Children's Hospital of Philadelphia found that the protein Vif is additionally involved in an earlier stage during the cell cycle, causing cells to move from the phase G1 to S , it latter characterized by a higher activity. This study is the first to demonstrate that a viral protein that can modulate cell cycle progression and, therefore, gives a little more light on the understanding of how is that the virus passes from a latent to active. The authors also found that Vif protein interacts with two cellular proteins: Brd4 and CDK9 . And although it was known that these proteins involved in cell cycle progression, the fact now known to be manipulated by the viral Vif protein makes them potential targets in the design of therapies. Of course, the latter will require more time and experiments, but bit by bit, molecule by molecule, protein-protein, we approach more effective therapies to control the lethal virus del sida. Artículo de referencia:

Wang, J., Reuschel, E., Shackelford, J., Jeang, L., Shivers, D., Diehl, J., Yu, X., & Finkel, T. (2010). HIV-1 Vif promotes the G1- to S-phase cell-cycle transition Blood, 117 (4), 1260-1269 DOI: 10.1182/blood-2010-06-289215